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Parasomnias: co-occurrence and genetics.

C Hublin1, J Kaprio, M Partinen

  • 1The Finnish Twin Cohort, Department of Public Health, University of Helsinki. christer.hublin@neuro.org

Psychiatric Genetics
|August 30, 2001
PubMed
Summary

Parasomnias like sleepwalking and nightmares often co-occur and run in families, suggesting a shared genetic influence. This study found significant genetic links between different parasomnias, indicating a common genetic background.

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Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Sleep Medicine

Background:

  • Parasomnias frequently exhibit familial aggregation and co-occurrence in clinical settings.
  • Previous research suggests a significant genetic contribution to the etiology of parasomnias.

Purpose of the Study:

  • To investigate the phenotypic covariation and shared genetic effects among five common parasomnias: sleepwalking, sleeptalking, enuresis, bruxism, and nightmares.
  • To determine the extent to which genetic factors contribute to the co-occurrence of these sleep disorders.

Main Methods:

  • Utilized data from the Finnish Twin Cohort, surveying 5856 individuals in childhood and 8567 as adults.
  • Employed polychoric correlations and structural equation modeling to analyze phenotypic covariation.
  • Analyzed shared genetic effects in 815 monozygotic and 1442 dizygotic twin pairs for adult parasomnia data.

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Main Results:

  • High co-occurrence was observed between sleeptalking and sleepwalking (childhood R=0.73, adult R=0.56), nightmares (childhood R=0.50, adult R=0.43), and bruxism (childhood R=0.43, adult R=0.39).
  • Strongest genetic covariation was identified between sleeptalking and sleepwalking (50%), sleeptalking and bruxism (30%), and sleeptalking and nightmares (26%).

Conclusions:

  • Parasomnias share a common underlying genetic etiology.
  • Genetic factors play a substantial role in the co-occurrence of various parasomnias, particularly involving sleeptalking.