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Conformational requirements at the prostaglandin cyclooxygenase receptor site
Agents and Actions. Supplements
|January 1, 1979
Abstract:
When space-filling models of the peroxy radical precursor of PGG were compared with models of 2(S)-(3-chloro-4-cyclohexylphenyl)propionic acid and other acidic cyclooxygenase inhibitors several common structural features were revealed. This led us to propose a template for synthesising non-steroidal anti-inflammatory drugs (NSAIS's) based on the geometry of the peroxy radical immediately prior to its cyclisation to PGG.