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Related Experiment Videos

Diffraction of partially coherent X-rays and the crystallographic phase problem.

A Szöke1

  • 1Department of Biochemistry, Biomedical Centre, Box 576, Uppsala University, S-75123 Uppsala, Sweden. szoke1@llnl.gov

Acta Crystallographica. Section A, Foundations of Crystallography
|August 30, 2001
PubMed
Summary

This study introduces a novel physical method using limited coherence X-ray beams to solve the crystallographic phase problem. This technique enables ab initio crystal structure determination by providing additional structural information beyond traditional Bragg conditions.

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Area of Science:

  • Crystallography
  • X-ray diffraction
  • Materials science

Background:

  • The crystallographic phase problem remains a significant challenge in determining atomic structures from diffraction data.
  • Traditional X-ray diffraction methods rely on Bragg conditions, limiting the information obtainable.
  • Developing new methods to overcome these limitations is crucial for advancing structural analysis.

Purpose of the Study:

  • To propose and describe a new physical method for partially solving the crystallographic phase problem.
  • To investigate the use of X-ray beams with limited coherence for structural analysis.
  • To demonstrate the potential for ab initio crystal structure determination using this novel approach.

Main Methods:

  • Illuminating crystal samples with X-ray beams of limited coherence.

Related Experiment Videos

  • Analyzing the resulting diffraction patterns, including broadened spots and continuous patterns.
  • Exploring conditions where the incident beam's coherence length is sufficiently small in all dimensions.

    • Main Results:

    • Diffraction spots broaden, and the pattern can become continuous when using X-rays with sufficiently limited coherence.
    • Independent structural information becomes accessible at both Bragg and non-Bragg angles.
    • Under specific conditions, the acquired information is adequate for ab initio crystal structure solution.

    Conclusions:

    • The proposed method offers a new physical route to address the crystallographic phase problem.
    • Limited coherence X-ray diffraction provides enhanced structural information compared to conventional methods.
    • This technique holds promise for ab initio structure determination in crystallography.