Related Experiment Video

Updated: Aug 16, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Developmental outcomes of infants with bronchopulmonary dysplasia: comparison with other medically fragile infants

D Holditch-Davis1, S Docherty, M S Miles

  • 1School of Nursing and Frank Porter Graham Child Development Center University of North Carolina at Chapel Hill, 27599, USA.

Research in Nursing & Health
|August 30, 2001
PubMed

Insights

Infants with bronchopulmonary dysplasia (BPD) show similar developmental outcomes and mother-infant interactions compared to other medically fragile infants. Chronic health issues, not BPD specifically, influence these behaviors.

Area of Science:

  • Neonatal Medicine
  • Developmental Psychology
  • Pediatric Health

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
  • Understanding developmental trajectories and mother-infant interactions is crucial for medically fragile infants.
  • Previous research suggested unique challenges for infants with BPD, necessitating further investigation.

Purpose of the Study:

  • To compare developmental outcomes and mother-infant interactions in infants with BPD versus other medically fragile infants.
  • To identify factors influencing these outcomes, including maternal behaviors and home environment.
  • To determine if observed differences are specific to BPD or related to broader chronic health issues.

Main Methods:

  • Longitudinal behavioral observations of mother-infant dyads (n=62) with BPD (n=23) and without BPD (n=39).
  • Assessments conducted during hospitalization, post-discharge, and at 6 and 12 months corrected age.
  • Statistical analysis using multiple regressions to examine predictors of developmental outcomes (mental, adaptive, language, motor).

Main Results:

  • No significant differences in developmental outcomes or interactive behaviors were found between infants with BPD and other medically fragile infants.
  • Intraventricular hemorrhage (IVH) did not significantly affect developmental or interactive variables.
  • Maternal positive attention and home environment positively correlated with mental development; maternal negative affect related to adaptive behavior.

Conclusions:

  • Developmental and interactive differences observed in infants with BPD are likely attributable to chronic health problems, not BPD exclusively.
  • Maternal interaction quality and the home environment are key factors in infant development for both groups.
  • Findings suggest a need for supportive interventions focusing on maternal behaviors and home environment for all medically fragile infants.

More Related Videos

Intratracheal Instillation of Stem Cells in Term Neonatal Rats04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Related Concept Videos

Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...