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Risperidone-associated new-onset diabetes.

D A Wirshing1, J M Pierre, J Eyeler

  • 1Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles School of Medicine, USA.

Biological Psychiatry
|August 31, 2001
PubMed
Summary

Novel antipsychotics like risperidone may cause diabetes, particularly in patients with existing risk factors. Weight gain is a key concern, necessitating careful monitoring of weight and glucose levels.

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Weight gain is a recognized complication of novel antipsychotic medications.
  • Associated health issues, including diabetes, are increasingly noted with these drugs.

Observation:

  • Two patients with schizophrenia developed diabetes mellitus while on risperidone.
  • Both patients exhibited pre-existing risk factors for diabetes.

Findings:

  • Insulin resistance and significant weight gain were observed in both cases.
  • Medical intervention was required, with one patient needing long-term insulin therapy.

Implications:

  • Weight gain is a significant risk factor for antipsychotic-induced diabetes.

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  • Regular monitoring of weight and fasting glucose is crucial for patients on novel antipsychotics.