Related Experiment Video
Updated: Jul 30, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
ABT-761 (Abbott)
1Primary Care Faculty of Medicine, Dunedin School of Medicine, University of Otago, New Zealand. jim.reid@stonebow.otago.ac.nz
Abstract:
Abbott's ABT-761 is a 5-lipoxygenase inhibitor with 8-fold increased potency over Bay-X-1005 and 150-fold over zileuton [171665]. It has a longer duration of action than its closest competitor, ZD-2138 (AstraZeneca), and has entered phase III trials for asthma [224216]. ABT-761 is the follow-up compound for zileuton and, due to its increased potency, requires only once-daily dosing [187700]. ABT-761 has shown excellent oral bioavailability and an extended duration of plasma levels in man, and initial results for a single 200 mg po dose have shown a significant protective effect against exercise- and adenosine-induced bronchoconstriction in asthmatics [215839]. The drug is well tolerated in healthy volunteers and shows linear pharmacokinetics. The pharmacokinetics in children are similar to that of adults.
More Related Videos
Related Concept Videos
Antibiotic Selection
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Abnormal Proliferation
Radical Substitution: Allylic Bromination
Abdominal Aorta
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Antibody Actions
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

