Related Experiment Videos
Effect of phlebography on 125I uptake test
AJR. American Journal of Roentgenology
|November 1, 1979
Summary
The 125I fibrinogen uptake test showed increased counts in many limbs after phlebography, but few cases progressed to symptomatic deep venous thrombosis. This suggests the test may have limited clinical utility for diagnosing DVT post-procedure.
Area of Science:
- Vascular Medicine
- Diagnostic Imaging
- Nuclear Medicine
Background:
- Ascending phlebography is a standard diagnostic tool for deep venous thrombosis (DVT).
- The 125I fibrinogen uptake test is used to detect DVT, but its utility after phlebography is unclear.
Purpose of the Study:
- To evaluate the incidence and significance of abnormal 125I fibrinogen uptake test results following a normal ascending phlebogram.
Main Methods:
- Fifty-five limbs underwent ascending phlebography, followed by 125I fibrinogen uptake testing.
- Abnormal uptake counts were analyzed for timing, location, and correlation with clinical DVT development.
Main Results:
- Increased 125I fibrinogen uptake was observed in 30 of 55 limbs, typically within 72 hours and often localized to the ankle.
- Only three patients with positive uptake counts developed symptomatic DVT, confirmed in two cases by repeat phlebography.
Conclusions:
- Elevated 125I fibrinogen uptake post-phlebography is common but infrequently associated with clinically significant deep venous thrombosis.
- The diagnostic value of the 125I fibrinogen uptake test in this specific post-procedural context appears limited.