Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Describing the pumping heart as a pressure source.

M Danielsen1, J T Ottesen

  • 1Department of Engineering, Trinity College, Connecticut, U.S.A.

Journal of Theoretical Biology
|August 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analytical solution of phosphate kinetics for hemodialysis.

Journal of mathematical biology·2023
Same author

Olive oil quality classification and measurement of its organoleptic attributes by untargeted GC-MS and multivariate statistical-based approach.

Food chemistry·2018
Same author

Multicenter study to assess presenteeism in systemic lupus erythematosus and its relationship with clinical and sociodemographic features.

Lupus·2017
Same author

A pilot study of a new assessment of physical activity in eating disorder patients.

Eating and weight disorders : EWD·2012
Same author

Functionality of the baroreceptor nerves in heart rate regulation.

Computer methods and programs in biomedicine·2010
Same author

Selective effects of 8-Br-cAMP on agonists and antagonists of the glucocorticoid receptor.

Endocrine·2010
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

A new mathematical model treats the heart as a pressure source, separating non-ejecting and ejecting properties. This approach challenges the independent view of time-varying elastance in cardiac function.

Area of Science:

  • Cardiovascular Physiology
  • Mathematical Modeling
  • Biomedical Engineering

Background:

  • The heart's function is complex, involving pressure generation, volume changes, and blood flow.
  • Existing models often simplify cardiac mechanics, potentially limiting their explanatory power.
  • The concept of time-varying elastance is widely used but its independence is debated.

Purpose of the Study:

  • To introduce a novel mathematical framework for describing the pumping heart.
  • To differentiate between isovolumic and ejecting phases of ventricular function.
  • To re-evaluate the role and independence of time-varying elastance.

Main Methods:

  • Developed a new mathematical approach modeling the heart as a pressure source.
  • Incorporated time, volume, and flow as determinants of cardiac pressure.

Related Experiment Videos

  • Separated isovolumic (non-ejecting) and ejecting heart properties in the model.

    • Main Results:

    • The model successfully describes human ventricular behavior under normal and altered vascular conditions.
    • Demonstrated that time-varying elastance is not an independent property.
    • Showed that time-varying elastance is a consequence of isovolumic properties and ejection effects.

    Conclusions:

    • The new mathematical approach provides a more comprehensive understanding of cardiac mechanics.
    • The study refutes the concept of time-varying elastance as an independent descriptor of heart function.
    • Ventricular ejection effects significantly influence the observed elastance dynamics.