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Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects
1Memorial University of Newfoundland, St. John's, Canada. rchandra@mun.ca
Nutrition (Burbank, Los Angeles County, Calif.)
|August 31, 2001
Summary
Supplementing elderly individuals with vitamins and trace elements significantly improved cognitive functions like memory and attention. This nutritional approach offers public health benefits and may help delay age-related cognitive decline.
Area of Science:
- Gerontology
- Nutritional Neuroscience
- Cognitive Health
Background:
- Cognitive decline is a significant concern in the elderly population.
- Maintaining cognitive function is crucial for independence and quality of life in older adults.
Purpose of the Study:
- To investigate the impact of modest vitamin and trace element supplementation on cognitive function in healthy elderly individuals.
- To assess changes in memory, abstract thinking, problem-solving, and attention.
Main Methods:
- A 12-month randomized, double-blind, placebo-controlled trial involving 96 healthy elderly participants (age > 65).
- Participants received daily supplements of vitamins and trace elements or a placebo.
- Cognitive function tests and blood-nutrient levels were assessed at baseline and study end.
Main Results:
- Significant improvements were observed in most cognitive tests for the supplemented group (P < 0.001 to 0.05), excluding long-term memory recall.
- Subjects with below-standard blood-nutrient levels showed diminished cognitive responses.
- No significant correlation was found between individual nutrient levels and cognitive performance.
Conclusions:
- Oral supplementation with vitamins and trace elements enhances cognitive functions in the elderly.
- This intervention has potential clinical and public health significance, improving daily living activities.
- Nutritional supplementation may play a role in delaying the onset of conditions like Alzheimer's disease.