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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Optimization of a screening lead for factor VIIa/TF
W B Young1, A Kolesnikov, R Rai
1Department of Medicinal Chemistry, Axys Pharmaceuticals, Inc., 385 Oyster Point Blvd., South San Francisco, CA 94080, USA. wendy_young@axyspharm.com
Bioorganic & Medicinal Chemistry Letters
|August 31, 2001
Abstract:
The structure-based design and progression of a screening lead to a 3nM factor VIIa/TF inhibitor with improved selectivity versus related enzymes is described.
