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A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
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Expression of natural peptide antibiotics in human articular cartilage and synovial membrane
F Paulsen1, T Pufe, W Petersen
1Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstr. 40, 24098 Kiel, Germany. fpaulsen@anat.uni-kiel.de
Clinical and Diagnostic Laboratory Immunology
|August 31, 2001
Abstract:
In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.
