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Related Experiment Videos

One versus two embryo transfer after IVF and ICSI: a randomized study.

H Martikainen1, A Tiitinen, C Tomás

  • 1Department of Obstetrics and Gynecology, Oulu University Central Hospital, Oulu, Finland. hmartika@cc.oulu.fi

Human Reproduction (Oxford, England)
|August 31, 2001
PubMed
Summary

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Transferring one embryo during in vitro fertilization (IVF) can achieve good pregnancy rates while avoiding dizygotic twins. This single embryo transfer policy supports improved outcomes in assisted reproduction.

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Embryo Transfer Strategies

Background:

  • High rates of multiple pregnancies are a primary cause of adverse outcomes in assisted reproduction.
  • Transferring a single embryo is the only method to prevent dizygotic (fraternal) twins.

Purpose of the Study:

  • To compare treatment outcomes between single embryo transfer and double embryo transfer.
  • To evaluate the feasibility of a single embryo transfer policy in IVF/intracytoplasmic sperm injection (ICSI).

Main Methods:

  • Randomized controlled trial involving 144 women with at least four good quality embryos.
  • Comparison of clinical pregnancy rates and cumulative pregnancy rates after fresh and frozen embryo transfers.
  • Analysis of twin delivery rates in both single and double embryo transfer groups.

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Main Results:

  • Clinical pregnancy rates per transfer were 32.4% for single embryo transfer and 47.1% for double embryo transfer (not statistically significant).
  • Eleven twin deliveries occurred in the double embryo transfer group; one monozygotic twin pair in the single embryo transfer group.
  • Cumulative pregnancy rates after fresh and frozen embryo transfers were 47.3% (single) and 58.6% (double).

Conclusions:

  • Single embryo transfer can yield good treatment results for women with good quality embryos in their first IVF/ICSI cycle.
  • A shift towards single embryo transfer policy is supported, with minimal impact on success rates.
  • This policy effectively prevents dizygotic twins, improving patient safety in assisted reproduction.