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Related Experiment Videos

Autophagy in yeast: mechanistic insights and physiological function.

H Abeliovich1, D J Klionsky

  • 1Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave., Ann Arbor, MI 48109, USA.

Microbiology and Molecular Biology Reviews : MMBR
|August 31, 2001
PubMed
Summary

Autophagy is a cellular recycling process essential for adaptation in yeast and animal cells. This review details autophagy mechanisms and physiological roles in both simple and complex organisms.

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Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris.

Molecular biology of the cell·2001

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Eukaryotic cells require adaptation mechanisms for survival in changing environments.
  • Autophagy, a catabolic process, degrades and recycles cellular components in response to stimuli like starvation.
  • Macroautophagy involves sequestering cytoplasmic material in autophagosomes for delivery to lysosomes or vacuoles.

Purpose of the Study:

  • To review insights into the mechanism of autophagy in yeast.
  • To examine the physiological significance of autophagy in both yeast and higher organisms.

Main Methods:

  • Review of existing literature on autophagy.
  • Analysis of conserved membrane-trafficking pathways involved in autophagy.
  • Comparison of autophagy mechanisms across different eukaryotic organisms.

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Main Results:

  • Autophagy utilizes conserved membrane-trafficking pathways, such as the cytoplasm-to-vacuole targeting pathway in yeast.
  • Mechanistic aspects of autophagy are constitutively functional, even when not induced.
  • Autophagy plays a crucial role in cellular homeostasis and adaptation.

Conclusions:

  • Autophagy is a fundamental cellular process with conserved mechanisms across eukaryotes.
  • Understanding autophagy in yeast provides insights into its function in higher organisms.
  • Autophagy is vital for cellular adaptation and survival under stress conditions.