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Related Experiment Videos

Focal prefrontal seizures induced by bilateral ECT.

L S Boylan1, D P Devanand, S H Lisanby

  • 1Department of Neurology, New York University School of Medicine, New York, New York, USA.

The Journal of ECT
|August 31, 2001
PubMed
Summary
This summary is machine-generated.

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Bilateral electroconvulsive therapy (ECT) may induce focal seizures in prefrontal areas, unlike right unilateral ECT. These seizures are more likely to occur later in the treatment course.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Devices

Background:

  • Bilateral (BL) electroconvulsive therapy (ECT) shows greater efficacy than right unilateral (RUL) ECT at low stimulus intensity.
  • Differences in seizure initiation site are proposed as a reason for this efficacy.
  • This study investigates the hypothesis that focal prefrontal seizures are more common with BL than RUL ECT.

Purpose of the Study:

  • To determine if bilateral ECT administration is associated with a higher incidence of focal prefrontal seizures compared to right unilateral ECT.
  • To explore the characteristics of electroencephalographic seizures without motor manifestations during ECT.

Main Methods:

  • A retrospective review of 1,007 electroconvulsive therapy (ECT) treatments was conducted.
  • Data from 84 consecutive patients randomized to either right unilateral (RUL) or bilateral (BL) electrode placement were analyzed.

Related Experiment Videos

  • Electroencephalographic (EEG) seizure activity without motor manifestations was identified.

    • Main Results:

    • Eight instances of electroencephalographic seizures without motor manifestations were recorded.
    • All identified events occurred during titration sessions and specifically with bilateral (BL) stimuli (p = 0.002).
    • These seizure events demonstrated a higher likelihood of occurring later in the course of ECT treatment.

    Conclusions:

    • Bilateral electroconvulsive therapy (ECT) may induce focal seizures, potentially in prefrontal areas.
    • The occurrence of these focal seizures appears to be more probable later in the treatment regimen.
    • Findings suggest a link between BL ECT, focal seizure activity, and treatment timing.