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Infections caused by Kluyvera species in humans

J C Sarria1, A M Vidal, R C Kimbrough

  • 1Division of Infectious Diseases, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. medjcs@ttuhsc.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 31, 2001
PubMed

Insights

Kluyvera infections, though rare, can be serious. Prompt antimicrobial treatment based on susceptibility testing leads to good outcomes, with key effective drugs including third-generation cephalosporins and fluoroquinolones.

Area of Science:

  • Microbiology
  • Infectious Diseases

Background:

  • Kluyvera, a genus in the Enterobacteriaceae family, infrequently causes human infections.
  • Its clinical significance remains debated, with varying classifications as saprophytic, opportunistic, or pathogenic.
  • Recent case reports highlight diverse Kluyvera infections since the genus redefinition in 1981.

Purpose of the Study:

  • To critically review all reported Kluyvera infections in the literature.
  • To present an additional 5 cases from the authors' experience.
  • To assess the clinical significance and treatment outcomes of Kluyvera infections.

Main Methods:

  • Comprehensive literature search for Kluyvera infection case reports.
  • Inclusion of 5 original patient cases.
  • Analysis of clinical data, antimicrobial susceptibility, and treatment outcomes.

Main Results:

  • Most patients received timely antimicrobial therapy guided by susceptibility testing.
  • Favorable clinical outcomes were observed in the majority of cases.
  • Effective antimicrobial agents included third-generation cephalosporins, fluoroquinolones, and aminoglycosides.
  • Significant resistance was noted against ampicillin, extended-spectrum penicillins, and earlier generation cephalosporins.

Conclusions:

  • Kluyvera is a potentially virulent pathogen requiring aggressive treatment.
  • Treatment strategies must consider the specific antimicrobial resistance patterns of Kluyvera strains.
  • Awareness of resistance profiles is crucial for effective management of Kluyvera infections.

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