Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Regulation of gene expression by action potentials: dependence on complexity in cellular information processing.

R D Fields¹, F Eshete, S Dudek

¹National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Novartis Foundation Symposium

|September 1, 2001

Summary

Neural impulse patterns regulate gene expression for nervous system adaptation. Intracellular signaling pathways decode spike frequency, influencing neurite outgrowth, plasticity, and memory.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-risk molecular features may eclipse genomic complexity in predicting chronic lymphocytic leukemia outcomes; UK clinical trial insights.

Leukemia·2026

Same author

Preliminary clinical evaluation: Where are we? An international scoping review.

Radiography (London, England : 1995)·2024

Same author

Bounding Global Aerosol Radiative Forcing of Climate Change.

Reviews of geophysics (Washington, D.C. : 1985)·2020

Same author

Ageing in corrective services: from the perspective of prison chaplains.

Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law·2020

Same author

Fetal ventricular strain in uncomplicated and selective growth-restricted monochorionic diamniotic twin pregnancies and cardiovascular response in pre-twin-twin transfusion syndrome.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019

Same author

Decreased pulmonary function in asymptomatic long-term survivors after allogeneic hematopoietic stem cell transplant.

Bone marrow transplantation·2015

Area of Science:

Neuroscience
Molecular Biology
Cellular Signaling

Background:

Neural impulse activity is crucial for nervous system development and plasticity.
The precise mechanisms by which action potential firing patterns regulate gene expression for long-term adaptation remain unclear.

Purpose of the Study:

To investigate how specific patterns of action potential firing regulate gene expression in neurons.
To elucidate the role of intracellular signaling cascades in decoding neural impulse activity.

Main Methods:

Utilized mouse sensory neurons in cell cultures.
Employed stimulating electrodes to control action potential firing patterns.
Analyzed intracellular signaling pathways including Ca2+, CaM KII, MAPK, and CREB.

Related Experiment Videos

Main Results:

Demonstrated that distinct action potential patterns can regulate specific genes.
Highlighted the critical role of temporal dynamics in intracellular signaling for information integration.
Identified key signaling pathways (Ca2+, CaM KII, MAPK, CREB) linking electrical activity to gene transcription.

Conclusions:

Action potential firing patterns directly influence gene expression critical for nervous system plasticity.
Intracellular signaling networks are essential for converting electrical signals into transcriptional changes.
These mechanisms contribute to neurite outgrowth, synaptic plasticity, and memory formation.