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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
Problems and prevention of viral hepatitis in Thailand
Y Poovorawan1, V Chongsrisawat, P Tangkijvanich
1Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Insights
Viral hepatitis remains a significant public health issue in Thailand. This review covers hepatitis A, B, C, D, E, G, TT, and SEN viruses, focusing on epidemiology, control, and prevention strategies.
Area of Science:
- Hepatology
- Virology
- Public Health
Background:
- Viral hepatitis poses a major public health challenge in Thailand, leading to chronic liver diseases like cirrhosis and hepatocellular carcinoma (HCC).
- Hepatitis A outbreaks persist despite declining rates, while Hepatitis D prevalence has decreased among intravenous drug users.
- Hepatitis E is an uncommon cause of acute hepatitis, and new viruses (G, TT, SEN) require further study for their role in liver disease.
Purpose of the Study:
- To review the current epidemiology of viral hepatitis in Thailand.
- To discuss molecular biology and control strategies for viral hepatitis.
- To highlight recent developments and research findings on hepatitis virus infections.
Main Methods:
- Review of current epidemiological data on viral hepatitis in Thailand.
- Analysis of molecular biology and pathogenesis of hepatitis viruses.
- Assessment of prevention and control strategies, including vaccination and public health interventions.
Main Results:
- Hepatitis B and C are leading causes of chronic liver disease and HCC.
- Hepatitis A outbreaks continue, while Hepatitis D prevalence has declined in specific populations.
- Effective vaccines exist for Hepatitis A and B, but not yet for Hepatitis C.
Conclusions:
- Viral hepatitis necessitates ongoing public health efforts in Thailand.
- Vaccination is key for Hepatitis A and B prevention.
- Further research is needed to understand and control emerging hepatitis viruses and Hepatitis C.
Abstract:
To this day, viral hepatitis remains a major public health problem in Thailand. Chronic infection with hepatitis B and C viruses are the leading causes of chronic liver diseases, including cirrhosis and hepatocellular carcinoma (HCC). Outbreaks of hepatitis A virus continue to occur in Thailand, even after several years of consistently declining prevalence rates. Also, the reduction in prevalence of hepatitis D virus infection has been observed among intravenous drug users over the past decade. Hepatitis E virus constitutes a rather unusual cause of sporadic acute hepatitis in Thailand. Highly effective vaccines are currently available for prevention of hepatitis A and B, however, as yet no effective vaccine for hepatitis C is imminent. Following rapid progress in the development of molecular techniques, several new hepatitis viruses have been identified. Among these, Hepatitis G, TT and SEN viruses have recently been described but their significance as to causation of human liver disease has yet to be established. This article reviews the current epidemiology, molecular biology, and strategies aimed at prevention and control of hepatitis virus infection in Thailand emphasizing new developments and recent data obtained from our research studies.
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