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Related Experiment Videos

Turner's syndrome.

M P Guarneri1, S A Abusrewil, S Bernasconi

  • 1Paediatric Department-Endocrine Unit Scientific Institute H San Raffaele, Milan, Italy. guarneri.mariapia@hsr.it

Journal of Pediatric Endocrinology & Metabolism : JPEM
|September 1, 2001
PubMed
Summary
This summary is machine-generated.

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Turner syndrome (TS) is a common sex-chromosome abnormality affecting females, causing short stature. Growth hormone (GH) therapy, sometimes combined with anabolic steroids, significantly improves final height in girls with TS.

Area of Science:

  • Genetics
  • Endocrinology
  • Pediatrics

Background:

  • Turner syndrome (TS) is the most frequent sex-chromosome abnormality in females.
  • Classical clinical findings include short stature and hypogonadism, with a significant growth deficit compared to the general population.

Framework:

  • Growth hormone (GH) therapy is recommended for improving final height (FH) in TS.
  • High-dose GH therapy (0.6-2 IU/kg/week) initiated in childhood is effective.

Implementation:

  • Combined therapy with anabolic steroids (e.g., oxandrolone) may further enhance FH.
  • Estrogen therapy, initiated at 13-14 years for hypogonadic patients, is crucial for pubertal development.

Implications:

  • Early estrogen therapy (before 12 years) may negatively impact FH.

Related Experiment Videos

  • Management of TS requires addressing concerns such as fertility and osteopenia alongside growth and puberty.