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Chronic myeloid leukemia presenting as gout.

K Pavithran1, M Thomas

  • 1Medical College Hospital, Trivandrum, India. drkpavithran@hotmail.com

Clinical Rheumatology
|September 1, 2001
PubMed
Summary

Gouty arthritis in a 53-year-old man was successfully treated, revealing an underlying chronic myeloid leukemia. Effective management led to complete arthritis remission and sustained hematologic remission.

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Area of Science:

  • Hematology
  • Rheumatology
  • Oncology

Background:

  • Gouty arthritis can be a presenting symptom of underlying hematologic malignancies.
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by uncontrolled proliferation of granulocytes.

Observation:

  • A 53-year-old male patient presented with symptoms indicative of gouty arthritis.
  • Initial diagnostic workup, including physical examination and laboratory tests, revealed the presence of chronic myeloid leukemia.

Findings:

  • The patient received a combination therapy including allopurinol, hydroxyurea, and analgesics for his condition.
  • Complete resolution of gouty arthritis was observed within two weeks of initiating treatment.
  • The patient achieved and maintained hematologic remission with interferon therapy, with no recurrence of gout.

Implications:

  • This case highlights the importance of considering systemic diseases in patients presenting with seemingly isolated symptoms like gout.
  • Prompt diagnosis and appropriate treatment of the underlying malignancy are crucial for managing associated complications.
  • Integrated management of hematologic malignancies and their rheumatologic manifestations can lead to favorable patient outcomes.

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