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Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic
W Dohle1, D M Lindsay, P Knochel
1Ludwig-Maximilians-Universität München, Institut für Organische Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Organic Letters
|September 1, 2001
Abstract:
[reaction: see text]. Functionalized arylmagnesium halides, prepared via an iodine-magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN.2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.