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Facile three-component coupling procedure for the synthesis of substituted tetrahydroisoindole-1,3-diones from
A Jacobi von Wangelin1, H Neumann, D Gördes
1Institut für Organische Katalyseforschung an der Universität Rostock e.V., Buchbinderstr. 5-6, 18055 Rostock, Germany.
Organic Letters
|September 1, 2001
Abstract:
[reaction: see text]. A new one-pot procedure for the efficient synthesis of a small library of amino-functionalized tetrahydroisoindole-1,3-dione derivatives was developed. This three-component coupling reaction comprises subsequent condensation and Diels-Alder reactions of ubiquitous available starting materials (alpha,beta-unsaturated aldehydes, amide, and maleimide). The synthesized compounds share a substituted tetrahydroisoindole motif in an endo fashion.