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Updated: Aug 14, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Choroidal neovascularization associated with aplasia of the optic nerve
D J Pieramici1, C Gonzalez, S C Raja
1Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, 600 North Wolfe St., Baltimore, MD 21287, USA. dpieramici@jhmi.edu
Purpose:
To report an unusual case of unilateral aplasia of the optic nerve associated with choroidal neovascularization.
Design:
Observational case report.
Methods:
In a 29-year-old female with optic nerve aplasia of the right eye and no choroidal neovascularization at age 23 years, choroidal neovascularization of the right eye was present by ophthalmoscopy and fluorescein angiography.
Results:
Fluorescein angiography disclosed de novo choroidal neovascularization corresponding to fibrovascular proliferation evident on ophthalmoscopy at age 29 years.
Conclusion:
Choroidal neovascularization may develop de novo during adult life in an eye with optic nerve aplasia.
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