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Updated: Aug 13, 2026

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Use of a protocol to minimize hypersensitivity reactions with asparaginase administration
Abstract:
Several antineoplastic drugs in clinical use may cause hypersensitivity reactions (HSRs) that range from an occasional individual reaction to a significant HSR. Asparaginase preparations have a high incidence of invoking HSRs. The use of an HSR protocol may minimize symptoms experienced by the patient and ensure rapid implementation of life-saving measures when reactions occur. The article will define HSRs, review occurrences, and include a protocol developed to minimize reactions to asparaginase preparations.

