Learning in respiratory control

In this article, it is argued that learning participates to fulfill the metabolic requirements by adapting respiratory control to changing internal and external states. Recent classical-conditioning experiments in newborn mice or adult rats show the close link between conditioned respiratory and arousal responses. The conditioned fear model may be a suitable and largely unexplored model of emotionally induced hyperventilation. The parabrachial nucleus and periacqueducal grey may play a pivotal role in the ventilatory component of conditioned fear. The sensitivity of breathing to conditioning in newborn and adult animals suggests that learning processes may shape breathing pattern throughout life.