Low-power water suppression by hyperbolic secant pulses with controlled offsets and delays (WASHCODE)

A class of chemical-shift-selective (CHESS) water suppression (WS) schemes is presented in which the characteristic frequency-domain excitation profiles of "adiabatic" full-passage (AFP) RF pulses are utilized for frequency-selective excitation of the water resonance. In the proposed WS schemes, dubbed WASHCODE, hyperbolic secant (HS) pulses were used as the AFP pulses. Besides the high immunity of WS efficiency toward B(1) inhomogeneity, these sequences also exhibit extraordinary insensitivity to the dispersion of the water T(1) relaxation times. The actual performance of the proposed WS schemes was achieved in particular by optimizing the frequency offsets of WS HS pulses and the time intervals between them. To reduce the RF power requirements of these WS sequences for in vivo applications, HS pulses with the minimum possible frequency bandwidths were employed, which also substantially reduced the adverse effects on the observed proton MR spectra. The proposed WS schemes were evaluated by simulations based on the Bloch equations. Several WS sequences which looked particularly promising were verified experimentally on the human brain on a 3 T MR scanner using very short echo-time STEAM for volume selection and a standard single-loop surface coil for both signal transmission and reception. Routinely, water-suppression factors ranging from 2000 to 4000 were achieved in vivo without additional adjustment of parameters for individual subjects and without violating legal safety limits.