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Prognostic immunohistochemical markers of primary human melanomas
1Fachklinik Hornheide, Dorbaumstrasse 300, D-48157 Münster, Germany.
Background:
Several clinical and histological factors of primary melanomas comprise a relatively large quantity of prognostic information.
Objective:
To find immunohistochemical markers that can improve the prognostic accuracy achieved by factors that are available without extra laboratory work, i.e. mitotic rate, tumour thickness, ulceration, localization, gender and age.
Methods:
Immunohistochemical markers were determined on frozen sections. Univariate and multivariate Cox regression analyses were performed after 5-10 years follow-up.
Results:
Seven immunohistochemical markers were related to disease-free and overall survival in univariate Cox regression analysis: Ki-67, human leucocyte antigen (HLA) -DQ, HLA-DP, Muc 18, A-10-33, transferrin receptor, and H-2-8-10. Only Ki-67 (n = 399) and HLA-DQ (n = 452) retained prognostic significance when evaluated in multivariate analyses in several models together with tumour thickness alone and with tumour thickness, gender, mitotic rate, age, localization and ulceration.
Conclusions:
Ki-67 and HLA-DQ may be useful for risk assessments in primary melanomas.