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Related Experiment Videos

Transient hyperphosphatasaemia: an important condition to recognize.

A J Carroll1, J C Coakley

  • 1Department of Paediatrics and Child Health, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia.

Journal of Paediatrics and Child Health
|September 5, 2001
PubMed
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Transient hyperphosphatasaemia (TH) is a common, benign condition in infants and children, often presenting with gastroenteritis during winter months. Early identification prevents misdiagnosis and unnecessary investigations.

Area of Science:

  • Pediatric Endocrinology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Transient hyperphosphatasaemia (TH) is a condition characterized by elevated alkaline phosphatase (ALP) levels in infants and children.
  • Distinguishing TH from other causes of high ALP, such as liver or bone disease, is crucial for appropriate patient management.

Purpose of the Study:

  • To determine the prevalence and causes of transient hyperphosphatasaemia (TH) in a pediatric hospital.
  • To establish diagnostic criteria for TH in children.

Main Methods:

  • Retrospective analysis of medical records for children with plasma alkaline phosphatase (ALP) activity exceeding 1000 U/L.
  • Exclusion of liver and bone disease as primary causes of elevated ALP.

Main Results:

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  • 68 children had ALP > 1000 U/L; TH accounted for 21 cases.
  • TH predominantly affected young males (mean age 1y 5m) and showed a winter seasonal peak, often following gastroenteritis.
  • Mean ALP in TH cases was 3395 U/L, normalizing within ~70 days.

Conclusions:

  • Transient hyperphosphatasaemia (TH) can be identified by age and exclusion of liver/bone disease, revealing a high prevalence.
  • Recognizing TH as a benign condition avoids misdiagnosis and unnecessary medical interventions.