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Acetazolamide poisoning in a toddler
Journal of Paediatrics and Child Health
|September 5, 2001
Summary
Acetazolamide overdose in children is rare but can cause severe metabolic acidosis. Prompt treatment with sodium bicarbonate led to a full recovery in a pediatric case, highlighting poisoning as a key diagnosis.
Area of Science:
- Pediatric toxicology
- Clinical chemistry
Background:
- Acetazolamide is a carbonic anhydrase inhibitor used to treat glaucoma and epilepsy.
- Data on acetazolamide toxicity in pediatric populations is limited.
Observation:
- A 12-month-old female child ingested 500-1250 mg of acetazolamide.
- The child presented with significant metabolic acidosis, with a maximum base deficit of 11.6.
Findings:
- Acetazolamide ingestion can lead to severe metabolic acidosis in children.
- Treatment with sodium bicarbonate is effective in reversing the acidosis.
Implications:
- Accidental acetazolamide poisoning should be considered in the differential diagnosis of pediatric metabolic acidosis.
- This case highlights the importance of considering environmental toxins in pediatric emergencies.