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NFAT signaling in vertebrate development.

I A Graef1, F Chen, G R Crabtree

  • 1Department of Developmental Biology, Stanford University Medical School, Stanford, CA 94305, USA.

Current Opinion in Genetics & Development
|September 5, 2001
PubMed
Summary
This summary is machine-generated.

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Nuclear Factor of Activated T-cells cytoplasmic (NFATc) proteins regulate gene transcription in response to calcium signals. Their evolution in vertebrates likely supports complex systems like the nervous and immune systems.

Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Immunology

Background:

  • Nuclear Factor of Activated T-cells cytoplasmic (NFATc) proteins are key signal transducers.
  • They link cytoplasmic calcium signals to nuclear gene transcription.
  • NFATc proteins form complexes that regulate gene expression in response to electrical and tyrosine kinase signaling.

Purpose of the Study:

  • To investigate the evolutionary origins and functions of NFATc proteins in vertebrates.
  • To explore the role of NFATc proteins in vertebrate-specific biological systems.

Main Methods:

  • Analysis of NFATc gene evolution at the origin of vertebrates.
  • Studies involving mice with null mutations in different NFATc family members.

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Main Results:

  • The four NFATc genes emerged at the vertebrate origin.
  • NFATc proteins are implicated in vertebrate-specific functions.
  • Studies using knockout mice support the proposed roles of NFATc proteins.

Conclusions:

  • NFATc proteins have evolved with vertebrates to support complex biological systems.
  • NFATc proteins play crucial roles in the development of the nervous, immune, and cardiovascular systems.