Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mammographic density changes during different postmenopausal hormone replacement therapies.

F Sendağ1, M Coşan Terek, S Ozşener

  • 1University Department of Obstetrics and Gynecology, Faculty of Medicine, Ege University, Azmir, Turkey. sendag@med.ege.edu.tr

Fertility and Sterility
|September 5, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global recommendations on adhesion prophylaxis in gynaecological laparoscopic surgery.

Facts, views & vision in ObGyn·2024
Same author

Evaluation of postoperative pain relief after pulpotomy using different procedures for disinfection and hemostasis in symptomatic irreversible pulpitis.

Nigerian journal of clinical practice·2023
Same author

Do tumor-infiltrating lymphocytes really indicate favorable prognosis in epithelial ovarian cancer?

European journal of obstetrics, gynecology, and reproductive biology·2017
Same author

Single Incision Laparoscopic Hysterectomy for Severe Endometriosis.

Journal of minimally invasive gynecology·2016
Same author

Laparoscopic Abdominal Cerclage.

Journal of minimally invasive gynecology·2016
Same author

Innovative Technique for Enclosed Morcellation Using a Surgical Glove.

Journal of minimally invasive gynecology·2016

Continuous postmenopausal hormone replacement therapy, particularly with progestin, significantly increases mammographic breast density. Estrogen-only or tibolone therapies showed minimal changes, highlighting regimen-specific effects.

Area of Science:

  • Endocrinology
  • Radiology
  • Women's Health

Background:

  • Postmenopausal hormone replacement therapy (HRT) is widely used for symptom management.
  • Changes in breast density during HRT can impact mammographic screening outcomes.
  • Understanding these changes is crucial for accurate interpretation of mammograms in women on HRT.

Purpose of the Study:

  • To evaluate the impact of different postmenopausal hormone replacement therapy regimens on mammographic breast density.
  • To identify specific HRT components or schedules associated with breast density changes.

Main Methods:

  • Retrospective analysis of mammograms from 216 postmenopausal women.
  • Classification of mammographic density using the Wolfe classification.
  • Comparison of density changes across various HRT types: estrogen alone, cyclic combined HRT, continuous combined HRT, and tibolone-only.

Related Experiment Videos

Main Results:

  • Continuous combined HRT significantly increased mammographic density (31.1%) compared to estrogen-only HRT (3.9%).
  • No significant density changes were observed with cyclic combined HRT or tibolone-only therapy.
  • The progestin component, especially in continuous regimens (e.g., norethisterone acetate 34.1%), appeared to be the primary driver of density increase.

Conclusions:

  • Mammographic breast density changes during postmenopausal HRT are dependent on the specific hormone regimen.
  • Continuous administration of progestin in combined HRT regimens is most strongly associated with increased breast density.
  • These findings have implications for mammographic screening interpretation in women using HRT.