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Serotonin and bipolar disorder.

T Mahmood1, T Silverstone

  • 1Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. tariqm@healthotago.co.nz

Journal of Affective Disorders
|September 5, 2001
PubMed
Summary
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Reduced central serotonin (5-HT) activity may indicate bipolar disorder. This serotonin deficiency is observed during depressive and euthymic phases, potentially serving as a trait marker for the illness.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Bipolar disorder pathogenesis is complex.
  • Serotonin (5-HT) systems are implicated in mood regulation.
  • Pharmacological tools for studying serotonin receptors have advanced.

Purpose of the Study:

  • To critically review the scientific literature on the relationship between bipolar disorder and serotonergic systems.
  • To investigate the role of serotonin in the pathogenesis of bipolar disorder.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of studies using pharmacological probes and radio-ligands for central serotonin (5-HT).

Main Results:

  • Evidence suggests reduced central serotonergic activity in the depressive phase of bipolar disorder.

Related Experiment Videos

  • Lower serotonin (5-HT) activity is also reported in euthymic bipolar patients, suggesting a potential trait marker.
  • Findings regarding serotonergic activity during the manic phase are inconsistent.

    • Conclusions:

    • Reduced central serotonin (5-HT) activity is a potential trait marker for bipolar disorder, particularly evident in depressive and euthymic states.
    • Further research is needed to clarify the role of serotonin in the manic phase of bipolar disorder.