Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure-function relationships of A-, F- and V-ATPases.

G Grüber1, H Wieczorek, W R Harvey

  • 1FR 2.5 Biophysik, Universität des Saarlandes, D-66421 Homburg, Germany. ggrueber@med-rz.uni-saarland.de

The Journal of Experimental Biology
|September 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid dose guidance in elective supraclavicular breast radiotherapy: a national survey of practice patterns in Switzerland.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2026
Same author

Efficacy and safety of Diclofenac sodium plaster in patients with acute pain of the limbs: a randomized, placebo and active-controlled, double-blind, parallel-group trial.

European review for medical and pharmacological sciences·2023
Same author

Novel Nanotube Multiquantum Dot Devices.

Nano letters·2022
Same author

Interrelation of Elasticity and Thermal Bath in Nanotube Cantilevers.

Physical review letters·2021
Same author

Author Correction: Fibrinogen - A Practical and Cost Efficient Biomarker for Detecting Periprosthetic Joint Infection.

Scientific reports·2020
Same author

Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient's perspective.

Breast cancer (Tokyo, Japan)·2020
Same journal

Interaction between dynamic reinforcement learning and working memory of pigeon: A comparative modeling study.

The Journal of experimental biology·2026
Same journal

Differential responses to photoperiod in juveniles of two migratory songbird species.

The Journal of experimental biology·2026
Same journal

A Drosophila overgrowth model reveals extracellular matrix crosslinking limits cardiovascular scaling.

The Journal of experimental biology·2026
Same journal

Control of High-speed Jumps: Removing rotation from the jumps of locusts (Schistocerca gregaria).

The Journal of experimental biology·2026
Same journal

Limits and mechanisms of honey bee colonial thermoregulation in the heat.

The Journal of experimental biology·2026
Same journal

Correction: Sprinting performance is linked to surface activity in scorpions.

The Journal of experimental biology·2026
See all related articles

This review compares the structures of A(1)-, F(1)-, and V(1)-ATPases, essential cellular energy converters. It highlights structural similarities and differences, particularly in their stalk regions, which link ATP hydrolysis to ion transduction.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Molecular Biology

Background:

  • Ion-translocating ATPases (ATP synthases) are crucial for cellular energy conversion.
  • These enzymes couple ATP hydrolysis to the generation of transmembrane ion gradients.
  • Families include F(1)F(o)-, V(1)V(o)-, and archaeal A(1)A(o) ATPases, sharing evolutionary origins but differing in function.

Purpose of the Study:

  • To review and compare the structural homologies and diversities of A(1)-, F(1)-, and V(1)-ATPases.
  • To focus on the structural relationships of major nucleotide-binding subunits (A/B and alpha/beta).
  • To examine the role and variations of stalk subunits in linking energy transduction.

Main Methods:

  • Comparative structural analysis of A(1)-, F(1)-, and V(1)-ATPase families.

Related Experiment Videos

  • Examination of primary structures and subunit compositions.
  • Review of recent structural studies focusing on nucleotide-binding and stalk regions.

    • Main Results:

    • A(1)-, F(1)-, and V(1)-ATPases exhibit evolutionary relationships based on subunit composition and structure.
    • Significant structural differences exist, especially within the stalk regions responsible for coupling.
    • Nucleotide-binding subunits (A/B and alpha/beta) show conserved structural features.

    Conclusions:

    • Despite shared ancestry, A(1)-, F(1)-, and V(1)-ATPases display distinct structural adaptations, particularly in their stalk regions.
    • Understanding these structural variations is key to elucidating their specific roles in cellular energy transduction.
    • Further structural insights are needed to fully comprehend the functional divergence among these enzyme families.