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Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infants
A Lucas1, M S Fewtrell, R Morley
1MRC Childhood Nutrition Research Centre, Institute of Child Health, London, England.
Pediatrics
|September 5, 2001
Summary
Nutritional intervention with postdischarge formula (PDF) improved growth in preterm infants up to 18 months. Further study is needed to confirm benefits for motor development.
Area of Science:
- Neonatal nutrition
- Pediatric growth and development
Background:
- Preterm infants often experience growth deficits post-discharge.
- Early childhood growth and neurodevelopment can be impacted by these deficits.
Purpose of the Study:
- To test if nutritional intervention in the first 9 months postterm reverses growth deficits.
- To evaluate the impact on neurodevelopment and safety outcomes.
Main Methods:
- 284 preterm infants (mean gestation 30.9 weeks) were studied.
- 229 infants were randomized to postdischarge formula (PDF) or standard term formula (TF).
- Anthropometry and developmental assessments (Bayley Scales) were performed up to 18 months.
Main Results:
- PDF group showed significantly greater weight and length at 9 months compared to TF.
- Length differences persisted at 18 months; no effect on head circumference.
- No significant difference in overall developmental scores, but a trend towards improved motor scores in the PDF group.
Conclusions:
- Postdischarge nutritional intervention may improve growth in preterm infants up to 18 months.
- The hypothesis that postdischarge nutrition benefits motor development requires further investigation.
- Breastfed preterm infants may benefit from nutritional supplementation.
