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Related Experiment Videos

A journey into space.

J Hayles1, P Nurse

  • 1Cell Cycle Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, UK. hayles@icrf.icnet.uk

Nature Reviews. Molecular Cell Biology
|September 5, 2001
PubMed
Summary
This summary is machine-generated.

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Fission yeast uses intracellular positional information, generated by microtubules and their transport, to grow straight and center its nucleus. These mechanisms are crucial for cell morphology and may apply to other eukaryotes.

Area of Science:

  • Cell Biology
  • Eukaryotic Molecular Biology

Background:

  • Fission yeast (Schizosaccharomyces pombe) is a model organism for studying cell cycle and morphology.
  • Cellular processes like straight-line growth and nuclear positioning rely on intracellular positional information.

Purpose of the Study:

  • To investigate the role of microtubules and microtubular transport in establishing intracellular positional information in fission yeast.

Main Methods:

  • Utilized fission yeast (Schizosaccharomyces pombe) as a model eukaryote.
  • Focused on cellular processes dependent on intracellular positional information.

Main Results:

  • Microtubules are essential for generating positional information in fission yeast.
  • Microtubular transport plays a key role in this process.

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Conclusions:

  • Intracellular positional information is critical for fission yeast growth and nuclear positioning.
  • The mechanisms involving microtubules and transport are likely conserved in other eukaryotic cells.