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Albumin genetic variability in South America: Population distribution and molecular studies
M.H.L.P. Franco1, S.O. Brennan, E.K.M. Chua
1Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil.
Abstract:
A total of 5,020 individuals living in two southern Brazilian states were screened in relation to albumin types; two variants were found, in Passo Fundo (Nagasaki 2) and Vera Cruz (Tradate 2). Another variant, detected in the northeast, was identified as Porto Alegre 2, which also occurs in other places in Brazil, as well as in India, Pakistan, and Turkey. The results were integrated with those obtained in other studies in South America, yielding a total of 16,941 Amerindians and 23,839 non-Indian subjects. Molecular and physiological studies performed in some of the variants suggested clues to explain the restricted distribution of albumin Yanomama 2 and the widespread occurrence of albumin Maku. Am. J. Hum. Biol. 11:359-366, 1999. Copyright 1999 Wiley-Liss, Inc.