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Honey, a prospective antibiotic: extraction, formulation, and stability.
A A Zaghloul1, H H el-Shattawy, A A Kassem
1School of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. Texas Tech University Health Science Center, Amarillo, TX, USA. abdel@cortex.ama.ttuhsc.edu
Die Pharmazie
|September 6, 2001
Summary
This study found that ethylacetate honey extract exhibits potent antimicrobial and antifungal properties. Honey extracts show promise for topical applications, with stability and release dependent on formulation.
Area of Science:
- Pharmacology
- Dermatology
- Microbiology
Background:
- Honey is traditionally recognized for its antiseptic and wound-healing properties.
- Its efficacy in treating skin infections and internal diseases is documented, but active components remain unclear.
Purpose of the Study:
- To evaluate the antimicrobial activity of crude honey.
- To isolate fractions responsible for honey's therapeutic effects.
- To develop semisolid dosage forms of honey extract and assess their release and stability.
Main Methods:
- Antimicrobial assays were performed on crude honey and its fractions.
- Honey extract was formulated into various ointment bases.
- In vitro release studies and stability testing (temperature and base dependency) were conducted.
Main Results:
- Ethylacetate honey extract demonstrated significant antibacterial, anticandida, and antifungal activity at low concentrations.
- The release profile of the honey extract varied based on the ointment base composition.
- Honey extract stability was influenced by both temperature and the specific ointment base used.
Conclusions:
- Ethylacetate fraction of honey possesses broad-spectrum antimicrobial activity.
- Honey extract can be formulated into stable semisolid dosage forms for topical use.
- Formulation excipients and storage conditions are critical for maintaining the efficacy and stability of honey-based topical treatments.