Effects of LSD-25 on performance of a visual discrimination task in brain-damaged rats

Rats subjected to either a frontal cortex lesion or to a sham operation were trained to discriminate between a lighted and unlit alley in order to escape shock. Following intubation with either placebo or LSD-25 (1.0 MG/KG), they were given discrimination trials 24 hr, 1 week, 2 weeks, 3 weeks, 4 weeks, and 5 weeks later. During the last 3 sets of trials, the discrimination task was increased in difficulty each week. A relatively long-term single-dose drug effect was observed in decreased accuracy of performance, with a drug-lesion interaction reflected in slower running time upon initial increase in level of task difficulty.