Dissolution studies on paracetamol solidified melt prepared under different cooling rates

Regulating the cooling rate of paracetamol melt resulted in the formation of different microcrystalline structures of the solidified melt. Dissolution rate studies were carried out on powdered samples prepared from fused paracetamol that was crystallized under different conditions. Rapid cooling associated with stirring the melt during crystallisation produced a fast rate of dissolution in the order of two times greater than the untreated drug. Increased dissolution rate data were masked to some extent when working with tablets prepared from the corresponsing solidified and powdered melts. The present study represent a new method of physical modification of drugs as a means of increasing rate of drug dissolution and absorption.