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Related Experiment Videos

Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates.

A M Wong1, S Musallam, R D Tomlinson

  • 1Division of Neurology, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.

Journal of the Neurological Sciences
|September 6, 2001
PubMed
Summary

Opsoclonus, a chaotic eye movement disorder, was studied in lung cancer patients. Findings suggest cerebellar fastigial nucleus dysfunction, specifically disinhibition, causes this condition.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Oncology

Background:

  • Opsoclonus is a rare, involuntary eye movement disorder.
  • Paraneoplastic syndromes can manifest with neurological complications, including opsoclonus.

Observation:

  • Magnetic scleral search coil technique used to study opsoclonus in two lung carcinoma patients.
  • Eye movements revealed opsoclonus as a three-dimensional oscillation (torsional, horizontal, vertical).
  • Anti-Ta antibodies found in one patient, a novel association with opsoclonus.

Findings:

  • Neuropathology showed mild paraneoplastic encephalitis and inflammation/gliosis in the fastigial nucleus.
  • Computer modeling indicated disinhibition of the cerebellar fastigial nucleus (FOR) generates opsoclonus.
  • Dysfunction of Purkinje cells inhibiting the FOR may cause opsoclonus.

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Implications:

  • Suggests cerebellar fastigial nucleus dysfunction is key in opsoclonus pathogenesis.
  • Highlights potential role of anti-Ta antibodies in paraneoplastic opsoclonus.
  • Informs understanding of neuro-ophthalmological manifestations of cancer.