Related Experiment Video
Updated: Oct 4, 2026
A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[Systemic antimicrobial treatment of prosthesis related infections: a comparative study of ornidazole and
E Stellini1, G Saler, S Grandesso
1Cattedra di Pedodonzia, Università degli Studi, Padova, Italy.
Background:
The aim of this study was to evaluate the efficacy of two chemotherapeutic agents against bacterial forms responsible for prosthesis-related infections.
Methods:
The evaluation was made on the basis of a count using optical microscope 1000x after GRAM staining of the main bacterial forms found in periprosthetic inflammatory exudate both before and after treatment. Two drugs used: ornidazole and minocycline. A group of 20 patients were studied (12 women and 8 men) aged between 42 and 71 years old with an advanced stage of periprosthetic inflammatory pathology. The pharmacological protocol was administered to the two groups of patients for a period of approximately 15 days.
Results:
At the end of treatment there was a marked reduction in all the bacterial forms involved in periprosthetic pathology in both groups, with a gradual recovery of normal bacterial flora (gram forms) coupled with a clinical improvement in the implant sites examined.
Conclusions:
Given the specificity of action shown by ornidazole against pathogenic anaerobic, gram-; bacteroides and sporigenic forms, it is recommended for systemic use against prosthesis-related inflammatory disease.
