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Related Experiment Videos

Chitosan-alginate-CaCl(2) system for membrane coat application.

L Wang1, E Khor, L Y Lim

  • 1Department of Chemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260.

Journal of Pharmaceutical Sciences
|September 6, 2001
PubMed
Summary

This study introduces a novel aqueous chitosan-alginate-CaCl(2) system for creating biodegradable polymer membranes. The developed system offers a stable, water-insoluble membrane formulation with tunable mechanical properties and reduced water vapor transmission.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomaterials Engineering

Background:

  • Water-based formulations are preferred for membrane applications to avoid hazardous solvents.
  • Biodegradable polymers offer sustainable alternatives in various applications.
  • Chitosan and alginate are biocompatible polysaccharides with potential for membrane fabrication.

Purpose of the Study:

  • To evaluate a novel aqueous chitosan-alginate-CaCl(2) system for producing water-insoluble biodegradable polymer membranes.
  • To investigate the effect of calcium chloride concentration on membrane properties.
  • To assess the storage stability and performance of chitosan-alginate coacervates.

Main Methods:

  • Preparation of chitosan-alginate coacervates from 0.25% (w/v) solutions.

Related Experiment Videos

  • Membrane casting and drying of coacervates in aqueous CaCl(2) solutions (0.05-0.07% w/v).
  • Characterization using tensile strength testing, water vapor transmission rate (WVTR) measurement, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and elemental analysis.

    • Main Results:

    • Increasing CaCl(2) content enhanced tensile strength from 9.33 to 17.13 MPa and reduced WVTR from 658 to 566 g/m(2)/day without altering membrane thickness (25-26 µm).
    • Chitosan-alginate coacervates demonstrated stability for up to 4 weeks in distilled water.
    • Membranes from stored coacervates required less calcium for maximum strength and exhibited higher WVTR compared to those from fresh coacervates.

    Conclusions:

    • The aqueous chitosan-alginate-CaCl(2) system is a viable formulation for creating water-insoluble biodegradable membranes.
    • The system allows for tuning mechanical properties and water vapor permeability through calcium content adjustment.
    • The storage stability of the coacervates suggests potential for practical application in membrane coating.