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The endocrine system in space flight.

C S Leach1, P C Johnson, N M Cintrón

  • 1NASA/Johnson Space Center, Biomedical Laboratories, Houston, TX 77058, USA.

Acta Astronautica
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Spaceflight alters key hormones regulating fluid balance and red blood cell production. Atrial natriuretic factor (ANF) initially rises then falls, while erythropoietin (Ep) decreases, indicating fluid shifts and potential renal changes.

Area of Science:

  • Space physiology
  • Endocrinology
  • Human physiology in microgravity

Background:

  • Hormones are critical for regulating body fluid, electrolyte, and calcium metabolism.
  • Traditional hormones like ADH, cortisol, and aldosterone do not fully explain fluid and electrolyte loss during spaceflight.
  • Atrial natriuretic factor (ANF) is a key regulator of sodium and water excretion.

Purpose of the Study:

  • To investigate the role of atrial natriuretic factor (ANF) in microgravity.
  • To assess changes in erythropoietin (Ep) and active vitamin D metabolite levels during spaceflight.
  • To understand hormonal responses to microgravity related to fluid, electrolyte, and calcium metabolism.

Main Methods:

  • Measurement of ANF in blood samples collected during spaceflight.
Keywords:
NASA Center JSCNASA Discipline Number 00-00NASA Discipline Number 21-50NASA Discipline Regulatory PhysiologyNASA Program Biomedical ResearchNASA Program Flight

Related Experiment Videos

  • Analysis of erythropoietin (Ep) levels from blood samples during the first Spacelab mission.
  • Monitoring of 1 alpha, 25-dihydroxyvitamin D3 levels during early flight phases.

    • Main Results:

    • Mean ANF levels were elevated after 30-42 hours of weightlessness, decreasing significantly by 175-180 hours.
    • Erythropoietin (Ep) levels were significantly decreased by the second day of flight.
    • The active vitamin D metabolite 1 alpha, 25-dihydroxyvitamin D3 increased early in flight.

    Conclusions:

    • Early elevation of ANF suggests a fluid shift in microgravity, followed by a compensatory decrease possibly due to reduced blood volume or increased renal blood flow.
    • Decreased Ep and increased vitamin D metabolite suggest altered renal blood flow and a stimulus for bone resorption during spaceflight.
    • Hormonal responses, including ANF, Ep, and vitamin D, are complex and play significant roles in adapting to microgravity.