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The involvement of cerebrovascular reactivity in pathogenesis of space motion sickness
Moskalenko YuE1, A I Beketov, G B Weinstein
1Institute of Evolutionary Physiology and Biochemistry, Acad. Sci. USSR, Leningrad.
Abstract:
The aim of the presented work is to investigate the mechanisms of involvement of cerebral circulation in pathogenesis of space motion sickness. In experiments on chronic rabbits the 2-hours rocking and antiorthostasis served as a model of influences of the zero-gravity conditions intracranial hemo- and liquorodynamics. Cerebravascular reactivity was evaluated as a response of cerebral blood flow and intracerebral rheoencephalography to functional loads (photostimulation, CO2-inhalation, Stookey test). Shifts of water balance in the brain tissue has been assessed by means of three-frequency brain electrical impedance. Rocking plus aniorthostatis resulted in decrease of the cerebrovascular reactivity and hyperhydration. The data obtained show a significant decrease of compensatory abilities of the cerebrovascular system under the zero-gravity conditions.