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Gravity dependent processes and intracellular motion.

P Todd1

  • 1National Institute of Standards and Technology, Boulder, CO 80303.

ASGSB Bulletin : Publication of the American Society for Gravitational and Space Biology
|July 1, 1991
PubMed
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Eukaryotic cells use cytoskeleton components to position organelles. Cell interiors are crowded, making natural-convective processes difficult to evaluate, especially with gravity-related forces.

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Organelle positioning in eukaryotic cells relies on the cytoskeleton.
  • The crowded intracellular environment complicates the study of natural-convective processes.
  • Cells exist in a state far from thermodynamic equilibrium due to solute exchange.

Purpose of the Study:

  • To explore the role of cytoskeleton in organelle positioning.
  • To understand the challenges in evaluating natural-convective processes within crowded eukaryotic cells.
  • To consider the influence of extracellular gravity-related forces on cellular functions.

Main Methods:

  • Review of existing literature on cytoskeleton function and intracellular transport.
  • Theoretical analysis of fluid dynamics and thermodynamics within a cellular context.

Related Experiment Videos

  • Examination of gravity-related forces impacting single-cell dynamics.

    • Main Results:

    • Cytoskeleton is crucial for maintaining organelle position against diffusion and crowding.
    • Natural convection is difficult to assess due to high intracellular viscosity and crowding.
    • Extracellular forces, like those from cell motility, can be significant.

    Conclusions:

    • The cytoskeleton is essential for intracellular organization.
    • Understanding cellular convection requires accounting for the unique crowded and non-equilibrium conditions.
    • Gravity-related forces and cell activity influence cellular dynamics.