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Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
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Dynamic roentgenographic changes in the empty sella syndrome.

C B Grossman

    Radiology
    |August 1, 1975
    PubMed
    Summary

    Two cases of empty sella syndrome show progressive sellar enlargement and increased intracranial pressure. One patient developed a new empty sella turcica, highlighting this condition

    Area of Science:

    • Neurology
    • Endocrinology
    • Radiology

    Background:

    • Empty sella syndrome (ESS) is a condition where the pituitary gland is compressed or absent within the sella turcica.
    • Idiopathic intracranial hypertension (IIH) can be associated with ESS, potentially exacerbating symptoms.
    • De novo development of ESS, particularly in the context of increased intracranial pressure, is uncommon.

    Purpose of the Study:

    • To present two clinical cases of empty sella syndrome.
    • To document the progression of sellar enlargement and associated increased intracranial pressure.
    • To highlight the occurrence of de novo empty sella turcica development.

    Main Methods:

    • Case report presentation.
    • Radiological imaging (e.g., MRI) to assess sellar morphology and intracranial pressure indicators.

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  • Clinical evaluation of symptoms related to increased intracranial pressure.
  • Main Results:

    • Progressive enlargement of the sella turcica was observed in both patients.
    • Evidence of increased intracranial pressure was documented in conjunction with sellar changes.
    • One patient demonstrated the spontaneous, de novo development of an empty sella turcica.

    Conclusions:

    • Empty sella syndrome can present with progressive sellar enlargement and signs of increased intracranial pressure.
    • The de novo development of empty sella turcica is a possible manifestation, particularly in cases with elevated intracranial pressure.
    • These cases underscore the importance of considering ESS in the differential diagnosis of sellar abnormalities and headaches.