Related Experiment Video
Updated: Aug 9, 2026

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix
Published on: July 10, 2016
Extracellular matrix and growth factors in branching morphogenesis
1Division of Biology, NSCORT, Kansas State University, Manhattan 66506, USA.
Abstract:
The unifying hypothesis of the NSCORT in gravitational biology postulates that the ECM and growth factors are key interrelated components of a macromolecular regulatory system. The ECM is known to be important in growth and branching morphogenesis of embryonic organs. Growth factors have been detected in the developing embryo, and often the pattern of localization is associated with areas undergoing epithelial-mesenchymal interactions. Causal relationships between these components may be of fundamental importance in control of branching morphogenesis.
Related Concept Videos
The Extracellular Matrix
Morphogenesis
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Overview of Cell-Matrix Interactions
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Extracellular Matrix

