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The Rhesus monkey as a model for testing the immunological effects of space flight.

G Sonnenfeld¹, L Schaffar, D A Schmitt

¹Department of Microbiology and Immunology, University of Louisville, KY 40292.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)

|January 1, 1994

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Rhesus monkeys show promise as a model for space flight

Area of Science:

Space immunology
Primate research

Background:

Space flight impacts immune systems in humans and rodents.
Rhesus monkeys are being explored as a potential model organism.

Purpose of the Study:

To assess the feasibility of using Rhesus monkey cells for space immunology studies.
To evaluate immune cell responses in Rhesus monkeys relevant to space flight effects.

Main Methods:

Immunophenotyping of lymph node and peripheral blood cells using monoclonal antibodies (CD4, CD8, Ia, surface immunoglobulin).
Assessing Ia antigen expression changes with human interferon-gamma treatment.
Inducing cytokine production (interferons, interleukins) and evaluating neutrophil oxidative burst.

Main Results:

Keywords:

NASA Discipline Cell Biology NASA Discipline Number 00-00 NASA Discipline Number 18-10 NASA Discipline Number 40-20 NASA Discipline Number 40-99 NASA Discipline Regulatory Physiology NASA Program Flight NASA Program Space Biology NASA Program Space Biology Research Associates NASA Program Space Physiology and Countermeasures Non-NASA Center

Related Experiment Videos

Rhesus monkey cells successfully stained for key immune surface markers.
Ia antigen expression increased upon human interferon-gamma treatment.
Cells produced interferons and interleukins; neutrophils showed enhanced oxidative burst.

Conclusions:

Rhesus monkey immune cells exhibit responses relevant to space flight.
These findings support the Rhesus monkey as a viable model for space immunology research.