Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptation to restraint in the rat.

V Popovic1

  • 1Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

The Physiologist
|January 1, 1988
PubMed
Summary

Physiological research using telemetry is developing. Studies on primates and rats in space require restraint devices, but rats showed no adaptation to restraint, with stress hormones remaining elevated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparation of male genital organs - a new autopsy technique.

Forensic science, medicine, and pathology·2026
Same author

Medical management pathways for Cushing's disease in pituitary tumors centers of excellence (PTCOEs).

Pituitary·2025
Same author

Standards of care for medical management of acromegaly in pituitary tumor centers of excellence (PTCOE).

Pituitary·2024
Same author

Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers.

Pituitary·2023
Same author

The persistence of seroprotective levels of antibodies after vaccination with PreHevbrio, a 3-antigen hepatitis B vaccine.

Vaccine·2023
Same author

Serum Insulin-Like Growth Factor-1 (IGF-1) Age-Specific Reference Values for Healthy Adult Population of Serbia.

Acta endocrinologica (Bucharest, Romania : 2005)·2022

Area of Science:

  • Physiological research
  • Space biology
  • Cardiovascular research

Background:

  • Telemetry use in physiological research is emerging.
  • Upcoming primate cardiovascular studies for gravitational research necessitate restraint devices.
  • Rat cardiovascular experiments for space missions utilize both unrestrained and semi-restrained models.

Purpose of the Study:

  • To determine if rats adapt to restraint by measuring plasma stress hormones.
  • To assess the impact of repeated restraint exposure on physiological stress markers in rats.

Main Methods:

  • Instrumented rats were exposed to restraint chambers 18 times.
  • Plasma stress hormone levels were measured to assess adaptation.

Main Results:

  • Repeated exposure to restraint chambers did not lead to adaptation.
  • Plasma stress hormone levels remained elevated despite multiple restraint sessions.

Conclusions:

  • Rats do not show adaptation to restraint conditions, as indicated by persistently elevated stress hormones.
  • The findings have implications for designing future space-based cardiovascular studies involving restrained animals.
Keywords:
NASA Discipline CardiopulmonaryNASA Discipline Number 00-00NASA Program FlightNon-NASA Center

Related Experiment Videos