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Unexpectedly facile synthesis of symmetrical P1,P2-dinucleoside-5'pyrophosphates
A Kanavarioti1, J Lu, M T Rosenbach
1Department of Chemsitry and Biochemistry, University of California, Santa Cruz 95064, USA.
Tetrahedron Letters
|January 1, 1991
Abstract:
Symmetrical dinucleoside 5'-pyrophosphates have been synthesized from the corresponding nucleoside 5'-phosphate free acid in high yield. The one-pot procedure is carried out in DMF or DMSO using triphenylphosphine and 2,2'-dipyridyldisulfide as the coupling agents, and 1-methylimidazole as the catalyst.