Inhibitory effect of nickel and chromium upon antibody response of rats to immunization with T-1 phage

Nickel and chromium significantly depressed the circulating antibody response of rats immunized with a viral antigen (T-1 phage). Consistent suppression of antibody was observed in all metal-treated animals; the greatest decrease in antibody titers was noted in animals receiving metals two weeks prior to the initial antigen dose.